Jesse Spencer (House MD - Doctor Robert Chase > Chicago Fire - Matthew Casey)
After his boss and mentor for almost a decade, Dr. Gregory House dies in a fire, Dr. Robert Chase, as we see in the finale, is given his old job. He is entertained by that for a time, but he is also haunted by the memory of House and how he died. This motivates him to drop everything, including his accent, move to Chicago and become a firefighter, vowing never to lose a loved one to the flames again.
Jordana Spiro (My Boys - PJ Franklin > Mob Doctor > Rachael Miller)
PJ loses her job as a columnist for the Times, because, well, it's a newspaper and there's no money in that anymore. She opts to go to her backup plan and opts to employ that secret medical degree she was sitting on. From there, she's just a favor for her brother away from getting in with the mob. Obviously, you are going to change your name if you are in with the mob, thus, she becomes Rachael.
Upon realizing that her fiance's job is in Miami, OH, she dumps that zero, and moves west (I'm guessing. They haven't addressed the location of the city yet. I'm assuming L.A.). I don't think anyone would be surprised to find out she has a medical degree all this time, but has been rebelling against her parents all this time. She partners up with a couple other doctors, starts going by her middle name and sets out on a new life.
Terry O'Quinn (LOST - John Locke > 666 Park Avenue - Gavin Doran)
Ok. This one's not even hard. Smoke monster John Locke gets off the island with Kate and the others, shacks up in New York city and plays a more upscale version of his old self. The woman he marries? I just assume she's insane or a creation of his.
Judy Miller grows tired of her slovenly husband and unappreciative children. She waits for the youngest child to graduates, kills her husband in his sleep. On her run from the cops, she meets a father and his children, on the run from the mafia. They agree to keep each other's identities concealed and move to a secretive neighborhood in a non-descript suburb. It turns out that they aren't the only one's hiding something in this new community though...
I won't pretend I finished Heroes, but I can only assume that Claire Bennett has a good reason to get away from it all. I'm pretty sure everyone she's ever known is dead or has betrayed her, so she is far more conniving. Considering that she is a looker and auto-tune does most of the work, she moves to Nashville to be a country singer, hiding in plain sight from those who with her dead. Giving her history, she distrusts authority figures or those considered wiser than her and it only makes sense that she would be determined to take down the reigning queen of country.
Giancarlo Esposito (Breaking Bad - Gustavo 'Gus' Fring > Revolution - Captain Tom Neville)
Did you really think Walter White would outsmart The Chicken Man? After pulling off one of the great "bait and switches" the world has ever seen in the events of "Face Off", he resurfaces as an insurance adjustor. "Coincidentally" not long after the world loses electricity. Of course, he survives the blackout and takes his bad-ass skills to the Monroe Republic militia.
Matthew Perry (Friends - Chandler Bing > Go On - Ryan King) - I'm choosing to ignore Studio 60 and Mr. Sunshine because...I want to. Poor Chandler's been through a lot. Monica died of a sudden and unexpected illness. This sends him into such a tailspin. No longer able to live in the real world, he creates a delusional world where he is a beloved sports radio host instead of a...I forget what his actual job is but it's quite insufferable. His only taste of reality is his weekly grief counseling group whose members he displaces all his insanity onto. It's really a very cerebral comedy. I'm surprised people say it has such broad appeal.
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